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Ms. Schmidt is a staff scientist in the Section on Neuroadaptation and Protein Metabolism in the Intramural Research Program of the National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. She received her M.A. in mathematics from the University of Maryland where she studied numerical linear algebra with G.W. Stewart. She joined the Laboratory of Cerebral Metabolism, NIMH in 1983 to work with Louis Sokoloff on quantitative in vivo imaging techniques. Ms. Schmidt’s current work centers on the development and analysis of kinetic models of tracers used for the measurement of regional cerebral blood flow, glucose metabolism, and protein synthesis by Positron Emission Tomography (PET) and quantitative autoradiographic techniques. |
Bishu S, Schmidt KC, Burlin TV, Channing MA, Conant S, Huang T-J, Liu Z-H, Qin M, Unterman A, Xia Z, Zametkin A, Herscovitch P, Smith CB. Regional rates of cerebral protein synthesis measured with L-[1-11C]leucine and PET in conscious, young adult men: normal values, variability, and reproducibility. J Cereb Blood Flow Metab 2008, 28:1502-1513 [pdf].
Smith CB, Schmidt KC, Bishu S, Channing M, Bacon J, Burlin T, Qin M, Liu ZH, Xia Z, Huang T, Vuong BK, Herscovitch P. Use of acute hyperphenylalaninemia in rhesus monkeys to examine sensitivity and stability of the L-[1-11C]leucine method for measurement of regional rates of cerebral protein synthesis with PET. J Cereb Blood Flow Metab 2008, 28:1388-1398 [pdf].
Schmidt KC, Cook MP, Qin M, Kang J, Burlin TV, Smith CB. Measurement of regional rates of cerebral protein synthesis with L [1 11C]leucine and PET with correction for recycling of tissue amino acids: I. Kinetic modeling approach. .J Cereb Blood Flow Metab 2005, 25:617-628 [pdf].
Smith CB, Schmidt KC, Qin M, Burlin TV, Cook MP, Kang J, Saunders RC, Bacher JD, Carson RE, Channing MA, Eckelman WC, Herscovitch P, Laverman P, Vuong B-K. Measurement of regional rates of cerebral protein synthesis with L [1 11C]leucine and PET with correction for recycling of tissue amino acids: II. Validation in rhesus monkeys. J Cereb Blood Flow Metab 2005, 25:629-640 [pdf].
Schmidt KC, Smith CB. Resolution, sensitivity and precision with autoradiography and small animal positron emission tomography: implications for functional brain imaging in animal research. Nuclear Medicine and Biology 2005, 32:719-725 [pdf].
Shimoji K, Ravasi L, Schmidt K, Soto-Montenegro ML, Esaki T, Seidel J, Jagoda E, Sokoloff L, Green MV, Eckelman WC. Measurement of cerebral glucose metabolic rates in the anesthetized rat by dynamic scanning with 18F-FDG, the ATLAS small animal PET scanner, and arterial blood sampling. J Nucl Med 2004, 45:665-672 [pdf].
Address: Building 10, Room 2D56, 10 Center Drive, Bethesda, MD 20892-1298
Phone: 301-402-3119
Fax: 301-480-1668
Email: Email Ms. Schmidt
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