Dr. Smith is Chief of the Section on Neuroadaptation and Protein Metabolism of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. Dr. Smith received a Ph.D. from the University of London where she studied the chemical pathology of Alzheimer's Disease with David Bowen, for which she was awarded the Queen Square Prize. She did postdoctoral training with Louis Sokoloff at NIMH and in 1986 became a Senior Investigator within the Laboratory of Cerebral Metabolism, NIMH. In 2000 Dr. Smith was awarded an honorary degree from the University of Linkõping for her work developing an in vivo quantitative autoradiographic method for measurement of regional rates of cerebral protein synthesis in experimental animals. This method was recently adapted for use in man with Positron Emission Tomography.
	Dr Smith’s group is currently studying mechanisms underlying brain dysfunction in fragile X syndrome and other neurodevelopmental disorders.
	Selected Publications: Bishu S, Schmidt KC, Burlin TV, Channing MA, Conant S, Huang T-J, Liu Z-H, Qin M, Unterman A, Xia Z, Zametkin A, Herscovitch P, Smith CB. Regional rates of cerebral protein synthesis measured with L-[1-11C]leucine and PET in conscious, young adult men: normal values, variability, and reproducibility. J Cereb Blood Flow Metab 2008, 28:1502-1513 [pdf]. Smith CB, Schmidt KC, Bishu S, Channing M, Bacon J, Burlin T, Qin M, Liu ZH, Xia Z, Huang T, Vuong BK, Herscovitch P. Use of acute hyperphenylalaninemia in rhesus monkeys to examine sensitivity and stability of the L-[1-11C]leucine method for measurement of regional rates of cerebral protein synthesis with PET. J Cereb Blood Flow Metab 2008, 28:1388-1398 [pdf]. Qin M, Smith CB. Regionally selective decreases in cerebral glucose metabolism in a mouse model of phenylketonuria. J Inherit Metab Dis 2007, 30:318-325 [pdf]. Qin M, Kang J, Smith CB. A null mutation for Fmr1 in female mice: Effects on regional cerebral metabolic rate for glucose and relationship to behavior. Neurosci 2005, 135:999-1009 [pdf]. Qin M, Kang J, Burlin TV, Jiang C, Smith CB. Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the Fmr1 null mouse. J Neuroscience 2005, 25(20):5087-5095 [pdf]. Smith CB, Kang J. Cerebral protein synthesis in a genetic mouse model of phenylketonuria. Proc Natl Acad Sci USA 2000, 97:11014-11019 [pdf]. Sun Y, Deibler GE, Jehle J, Macedonia J, Dumont I, Dang T, Smith, CB. Rates of local cerebral protein synthesis in the rat during normal postnatal development. Am J Physiol 1995, 268:R549-R561 [pdf]. Smith CB, Deibler GE, Eng N, Schmidt K, Sokoloff L. Measurement of local cerebral protein synthesis in vivo: Influence of recycling of amino acids derived from protein degradation. Proc Natl Acad Sci USA 1988, 85:9341-9345 [pdf]. Hajime Nakanishi, Yun Sun, Richard K. Nakamura, Kentaro Mori, Masanori Ito, Sumio Suda, Hiroki Namba, Fredric I. Storch, Thao P. Dang, Wallace Mendelson, Mortimer Mishkin, Charles Kennedy, J. Christian Gillin, Carolyn Beebe Smith and Louis Sokoloff. Positive Correlations Between Cerebral Protein Synthesis Rates and Deep Sleep in Macaca mulaffa. European Journal of Neuroscience, Vol. 9, pp. 271-279, I997 [pdf]. M. C. Ingvar, P. Maeder, L. Sokoloff and C. B. Smith. Effects of Ageing on Local Rates of Cerebral Protein Synthesis in Sprague-Dawley Rats. Brain, 108, 155-170, 1985 [pdf].
	Address:  Building 10, Room 2D56, 10 Center Drive, Bethesda, MD 20892-1298 Phone:     301-402-3120 Fax:          301-480-1668 Email:      Email Dr. Smith

This page was last edited: 10 December 2008.

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