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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Principal Investigators Yin Yao, Ph.D.   Dr. Yin Yao obtained her PhD from the Columbia University in New York City in 1996. After working one year as a postdoc fellow in the International Agency of Research on Cancer in Lyon, France, Dr. Yao returned to the States. She served as a Research Assistant Professor in University of Pittsburgh for one year and then took a Statistical Geneticist position at the Center for the Inherited Disease at Johns Hopkins University for two years. She then worked as a tenure-track faculty member in the Department of Epidemiology of Bloomberg School of Public Health at Johns Hopkins University between 2001 and 2007. She was Promoted to Associate Professor in 2005. In 2007, Dr. Yao moved to the extramural program of NIMH to lead the program of Genetic Epidemiology while she maintained her research interest in method development. In the beginning of 2011, Dr. Yao took a position as the Chief of the Unit on Statistical Genomics at the Intramural Research Program (IRP) of NIMH. Research Interests Her current research interests include method development for analyzing next generation sequencing data and for data dimension reduction. She will also collaborate with both intramural and extramural scientist to apply the most effective statistical methods to analyze the emerging data sets with complex data structure, and mainly focus on mental health disorders and biomarker studies related to drug efficacy or side effects. Representative Selected Recent Publications: Xu FH, Xiong D, Xu YF, Cao SM, Xue WQ, Qin HD, Liu WS, Cao JY, Zhang Y, Feng QS, Chen LZ, Li MZ, Liu ZW, Liu Q, Hong MH, Shugart YY, Zeng YX, Zeng MS, Jia WH.: An epidemiological and molecular study of the relationship between smoking, risk of nasopharyngeal carcinoma, and epstien-barr virus activation. J Natl Cancer Inst., 104 (18):1396-410, 2012. Guo W, Shugart YY: Detecting rare variants for quantitative traits using nuclear families.. Hum Hered., 73(3):148-58, 2012. Kiezun A, Garimella K, Do R, Stitziel NO, Neale BM, McLaren PJ, Gupta N, Sklar P, Sullivan PF, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Lehner T, Shugart YY, Price AL, de Bakker PI, Purcell SM, Sunyaev SR.: Exome sequencing and the genetic basis of complex traits. Nat Genet., 44(6):623-30, 2012. Ruczinski I, Jorgensen TJ, Shugart YY, Schaad YB, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ.: A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype. Carcinogenesis, 3(9):1692-8, 2012. Akula N, Detera-Wadleigh S, Shugart YY, Nalls M, Steele J, McMahon FJ.: Identity-by-descent filtering as a tool for the identification of disease alleles in exome sequence data from distant relatives. BMC Proc., Suppl 9:S76, 2011. Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, Kassem L, Park JH, Chatterjee N, Jamain S, Cheng A, Leboyer M, Muglia P, Schulze TG, Cichon S, Nöthen MM, Rietschel M; BiGS, McMahon FJ.: Genome-wide association study meta-analysis of European and Asian-ancestry samples: identifies three novel loci associated with bipolar disorder. Mol Psychiatry, Dec 20. doi: 10.1038/mp.2011.157, 2011. Qin HD, Shugart YY, Bei JX, Pan QH, Chen L, Feng QS, Chen LZ, Huang W, Liu JJ, Jorgensen TJ, Zeng YX, Jia WH. : Comprehensive pathway-based association study of DNA repair gene variants and the risk of nasopharyngeal carcinoma. Cancer Res, 71(8):3000-8, 2011. Address: Unit on Statistical Genomics Bldg. 35 Room 3A100 35 Convent Drive Bethesda, MD 20892 Phone: 301-496-4341 Email Dr. Yao Fax: Lab Web Site:     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Neurophysiology Imaging Facility Scientific and Statistical Computing Core Section on Instrumentation Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) which is a part of the National Institutes of Health (NIH), a component of the U.S. Department of Health and Human Services.