Transforming the understanding and treatment of mental illness through research
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 Principal Investigators

Daniel Pine, M.D.
Daniel Pine Photo   Dr. Daniel Pine is currently Chief, Section on Development and Affective Neuroscience of the National Institute of Mental Health Intramural Research Program. Dr. Pine moved to this position in the fall of 2000, after 10 years of training, teaching and research at the Department of Child and Adolescent Psychiatry in the New York State Psychiatric Institute and the College of Physicians and Surgeons of Columbia University. Since graduating from medical school at the University of Chicago, Dr. Pine has been engaged continuously in research focusing on the epidemiology, biology and treatment of psychiatric disorders in children and adolescents. His areas of expertise include biological and pharmacological aspects of mood, anxiety and behavioral disorders in children, as reflected in a series of more than 200 papers on these topics. Dr. Pine also possesses expertise in the biological commonalities and differences among psychiatric disorders of children, adolescents and adults as well as on interfaces between psychiatric and medical disorders. His most recent work uses methods from neuroscience to study normal and abnormal emotional development. Dr. Pine has received a number of awards, including Career Development and R01 extramural grant support from the NIMH, a NARSAD Independent Investigator Award, the Joel Elkes Award from the American College of Neuropsychopharmacology, as well as the Blanche Ittelson Award from the American Psychiatric Association for outstanding research contributions to the field of child psychiatry.  He also remains quite involved in research on therapeutics, having served as Chair of the Food and Drug Administration Psychopharmacology Drug Advisory Board.
Research Interests
My research interests as an academic child psychiatrist include two complimentary avenues. First, I am testing hypotheses on brain-behavior associations in childhood psychopathology. Second, I am an active investigator in pediatric psychopharmacology.

With respect to brain-behavior associations, I have conducted a series of studies examining the pathophysiology of anxiety disorders in children and adults over the past decade. Much of my initial work in this area relied upon psychophysiologic or neuropsychological experimental paradigms.
Representative Selected Recent Publications:
  • Beesdo K, Lau J, McClure-Tone EB, Guyer AE, Monk CS, Neslon EE, Fromm SJ, Goldwin MA, Wittchen H-U, Leibenluft E, Ernst M, Pine DS: Common and specific amygdala-function perturbations in depressed versus anxious adolescents.  Arch Gen Psychiatry, 2009; 66: 275-85.
  • Alvarez RP, Biggs A, Chen G, Pine DS, Grillon C: Contextual fear conditioning in humans: cortical-hippocampal and amygdala contributions.  J Neuroscience, 2008; 28: 6211-9.
  • Blair K, Geraci M, Devido J, McCaffrey D, Chen G, Vythilingam M, Ng P, Hollon N, Jones M, Blair RJR, Pine DS: The neural response to self-and-other-referential praise and criticism in generalized social phobia.  Arch Gen Psychiatry, 2008; 65: 1176-84.
  • Pine DS, Helfinstein SM, Bar-Haim Y, Nelson E, Fox NA: Challenges in developing novel treatments for childhood disorders: lessons from research on anxiety.  Neuropsychopharmacology, 2009; 34: 213-28.
  • Guyer AE, Lau JYF, McClure-Tone EB, Parrish J, Shiffrin ND, Reynolds RC, Chen G, Blair RJR, Leibenluft E, Fox NA, Ernst M, Pine DS, Nelson EE:   Amygdala and ventrolateral PFC function during anticipated peer evaluation in pediatric social anxiety.  Arch Gen Psychiatry, 2008; 65: 1303-12
  • Blair K, Shaywitz J, Smith BW, Rhodes R, Geraci M, Jones M, McCaffrey D, Vythilingam M, Finger E, Mondillo K, Jacobs M, Charney DS, Blair RJ, Drevets WC, Pine DS: Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders.  Am J Psychiatry, 2008; 165: 1193-202..  


NIMH, 15K North Drive, MSC-2670, Bethesda, MD 20892-2670

Phone: 301.594.1318
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This page was last updated January 13, 2012.

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