| | Principal Investigators
| David M. Jacobowitz,
Ph.D. |
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Dr.
Jacobowitz is Chief of the Section
on Histopharmacology, Laboratory of Clinical Science,
at the National Institute of Mental Health in Bethesda
Maryland. He received a Masters Degree in Anatomy, and
a Ph.D. in Pharmacology at Ohio State University School
of Medicine. He spent nine years on the staff of the Pharmacology
Department at the University of Pennsylvania Medical School
before joining the faculty of NIMH. He has recently produced
the state-of-the-art color atlas entitled, "Chemoarchitectonic
Atlas of the Developing Mouse Brain". |
| Research Interests |
| Dr. Jacobowitz's work has focused on brain neurochemicals and mapping of neural systems of the brain. As a major repository of information concerning sites of localization for potent brain neurochemicals, the lab has given birth to a field of neuroscience that Dr. Jacobowitz described as "brain cartography". His guiding principle is that knowledge of the building blocks, or "nuts and bolts," give us clues about how the nervous systems operate and how they might fail to disease and injury. Dr. Jacobowitz's laboratory is currently engaged in proteomics towards protein discovery in diseased human brains and those of mutant rodent models in addition to neuronal cells in culture. |
| Representative Selected Recent Publications: |
- Harashima C, Jacobowitz DM, Witta J, Borke RC, Best TK, Siarey RJ, Galdzicki Z:
Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome.
Journal of Comparative Neurology, 494: 815-833, 2006.
- Jacobowitz DM, Kresse A, Skofitsch G:
Galanin in the brain: chemoarchitectonics and brain cartography-a historical review.
Peptides, 25: 433-464, 2004. (View PDF)
- Madhavarao CN, Moffett JR, Moore RA, Viola RE, Namboodiri MA, Jacobowitz DM:
Immunohistochemical localization of aspartoacylase in the rat central nervous system.
Journal of Comparative Neurology, 472: 318-329, 2004. (View PDF)
- Jacobowitz DM, Abbott LC, Kallarakal AT, Tohda C, Lau FC, Gillespie JW:
Normal Brain Development and Gene Discovery in the Embryo. In: Pathology of Genetically-Engineered Mice.
Eds: Ward, J.M., Mahler, J., Maronpot, R. and Sundberg, J.P., pp. 123-134, 2000.
- Jacobowitz DM, Abbott LC:
Chemoarchitectonic Atlas of the Developing Mouse Brain.
CRC Press, Boca Raton, Florida, 1998.
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