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Transforming the understanding and treatment of mental illness through research
DIVISION OF INTRAMURAL RESEARCH PROGRAMS
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 Principal Investigators

James Blair, Ph.D.
James Blair Photo James Blair is Chief of the Unit on Affective Cognitive Neuroscience at NIMH. Dr Blair received a doctoral degree in Psychology from University College London in 1993 under the supervision of Professor John Morton. Following graduation he was awarded a Wellcome Trust Mental Health Research Fellowship that he held at the Medical Research Council Cognitive Development Unit for three years. Subsequently, he moved to the Institute of Cognitive Neuroscience, University College London. There, with Uta Frith, he helped form and co-lead the Developmental Disorders group, and was ultimately appointed Senior Lecturer. He Joined the NIMH Intramural Research Program in 2002.
Research Interests
Dr. Blair's primary research interest involves understanding the neuro-cognitive systems mediating affect in humans and how these become dysfunctional in mood and anxiety disorders. His primary clinical focus is in understanding the dysfunction of affect-related systems in youth with specific forms of conduct disorder. His research approach includes techniques employed in cognitive neuroscience (both neuropsychology and functional imaging), psychopharmacology and, more recently, molecular genetics.
Representative Selected Recent Publications:
  • Finger E C, Marsh A A, Blair K S, Reid M E, Sims C, Ng P, et al. Disrupted reinforcement signaling in the orbitofrontal cortex and caudate in youths with conduct disorder or oppositional defiant disorder and a high level of psychopathic traits. Am J Psychiatry, 168(2), 152-162, 2011. (View)
  • Luo Q, Holroyd T, Majestic C, Cheng X, Schechter J C, Blair R J R. Emotional automaticity is a matter of timing. Journal of Neuroscience, 30, 5825-5829, 2010. (View)
  • Hasler G, Mondillo K, Drevets W C, Blair R J R. Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion. Neuropsychopharmacology, 34(13), 2691-2698, 2009. (View)
  • Mitchell D G, Luo Q, Avny S B, Kasprzycki T, Gupta K, Chen G, et al. Adapting to dynamic stimulus-response values: differential contributions of inferior frontal, dorsomedial, and dorsolateral regions of prefrontal cortex to decision making. Journal of Neuroscience, 29, 10827-10834, 2009. (View)
  • Finger E C, Marsh A A, Mitchell D G V, Reid M E, Sims C, Budhani S, et al. Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning. Archives of General Psychiatry, 65(5), 586-594, 2008. (View)
  • Marsh A A, Finger E C, Mitchell D G V, Reid M E, Sims C, Kosson, D S, et al. Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders. American Journal of Psychiatry, 165(6), 712-720, 2008. (View)

Address:
9000 Rockville Pike
Building 15K, Room 206
Bethesda MD 20892
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This page was last updated September 13, 2012.


  The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) which is a part of the National Institutes of Health (NIH), a component of the U.S. Department of Health and Human Services.
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