| | Principal Investigators
| James Blair, Ph.D. |
 |
James Blair is Chief of the Unit
on Affective Cognitive Neuroscience at NIMH. Dr Blair received a doctoral
degree in Psychology from University College London in 1993 under the supervision of Professor John Morton.
Following graduation he was awarded a Wellcome Trust Mental Health Research Fellowship that he held at the
Medical Research Council Cognitive Development Unit for three years. Subsequently, he moved to the Institute of
Cognitive Neuroscience, University College London. There, with Uta Frith, he helped form and co-lead the
Developmental Disorders group, and was ultimately appointed Senior Lecturer. He Joined the NIMH Intramural
Research Program in 2002. |
| Research Interests |
| Dr. Blair's primary research interest involves understanding the neuro-cognitive systems mediating affect in humans and how these become dysfunctional in mood and anxiety disorders. His primary clinical focus is in understanding the dysfunction of affect-related systems in youth with specific forms of conduct disorder. His research approach includes techniques employed in cognitive neuroscience (both neuropsychology and functional imaging), psychopharmacology and, more recently, molecular genetics. |
| Representative Selected Recent Publications: |
- Finger E C, Marsh A A, Blair K
S, Reid M E, Sims C, Ng P, et al. Disrupted
reinforcement signaling in the orbitofrontal cortex
and caudate in youths with conduct disorder or
oppositional defiant disorder and a high level
of psychopathic traits. Am J Psychiatry,
168(2), 152-162, 2011. (View)
- Luo Q, Holroyd T, Majestic C, Cheng
X, Schechter J C, Blair R J R. Emotional
automaticity is a matter of timing. Journal of
Neuroscience, 30,
5825-5829, 2010. (View)
- Hasler G, Mondillo K, Drevets W C, Blair
R J R. Impairments of probabilistic response
reversal and passive avoidance following catecholamine
depletion. Neuropsychopharmacology, 34(13),
2691-2698, 2009. (View)
- Mitchell D G, Luo Q, Avny S B,
Kasprzycki T, Gupta K, Chen G, et al. Adapting
to dynamic stimulus-response values: differential
contributions of inferior frontal, dorsomedial,
and dorsolateral regions of prefrontal cortex to
decision making. Journal of Neuroscience, 29,
10827-10834, 2009. (View)
- Finger E C, Marsh A A, Mitchell
D G V, Reid M E, Sims C, Budhani S, et
al. Abnormal ventromedial prefrontal cortex
function in children with psychopathic traits during
reversal learning. Archives of General Psychiatry, 65(5),
586-594, 2008. (View)
- Marsh A A, Finger E C, Mitchell D
G V, Reid M E, Sims C, Kosson, D S, et al. Reduced
amygdala response to fearful expressions in children
and adolescents with callous-unemotional traits and
disruptive behavior disorders. American Journal
of Psychiatry, 165(6), 712-720, 2008. (View)
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Address:
|
9000 Rockville Pike
Building 15K, Room 206
Bethesda MD 20892 |
| Phone: |
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| Email Dr. Blair |
| Fax: |
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| Lab Web Site: |
No Website available |
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