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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Principal Investigators Peter A. Bandettini, Ph.D. Dr. Bandettini is Chief of the Section on Functional Imaging Methods in the Laboratory of Brain and Cognition of the Intramural Research Program. He is also the director of the Functional MRI Core Facility, which maintains cutting edge fMRI capability (one 1.5T human scanner, three 3T human scanners and a planned 7T human scanner) to over 30 fMRI research teams within NIMH and NINDS. Dr. Bandettini received his B.S. in Physics from Marquette University in 1989 and his Ph.D. in Biophysics from the Medical College of Wisconsin in 1994, where he worked on the early development of magnetic resonance imaging of human brain function using blood oxygenation contrast - known as functional MRI (fMRI). While in graduate school, he published one of the first three papers in fMRI in 1992. During his postdoctoral fellowship at the Massachusetts General Hospital, he continued his investigation of methods to increase the interpretability, resolution, and applicability of functional MRI techniques. In 1999, he joined NIMH. In 2001, he was awarded the Scientific Director's Merit Award for his efforts in establishing the NIH FMRI core facility. In 2002, he was awarded the Wiley Young Investigator's at the annual Organization for Human Brain Mapping Meeting. In 2005, he served as president of the Organization for Human Brain Mapping. He is currently the associate editor of the two primary journals in brain mapping: Human Brain Mapping and NeuroImage. Since the start of his career, he has published about 85 papers, 250 abstracts, 16 book chapters, and 1 book. He has also presented over 240 invited lectures. His laboratory is currently developing MRI methods improve the spatial resolution, temporal resolution, sensitivity, interpretability, and applicability of functional MRI. Research Interests The Research of the Section on Functional Imaging Methods resides directly at the interface of basic neuroscience, functional MRI methods, and clinical applications. The general research goals include the development of novel pulse sequences, brain activation paradigm, and processing methods so that more detailed, subtle, and clinically relevant information may be extracted from fMRI and anatomical data. Specifically, we are extremely interested in 1) understanding, and separating the neuronal and physiologic influences on spontaneous oscillations, 2) the continued development, optimization and utilization of multivariate "fMRI decoding" techniques as a complement to more standard mapping techniques, 3) understanding and separating the neuronal and physiologic influences on fMRI signal dynamics such as the post undershoot and dynamic nonlinearity, and 4) optimizing "embedded contrast" pulse sequences which would allow simultaneous extraction and detailed comparison of cerebral blood flow, oxygenation, and volume; with the goal being a method to quantify resting and active blood oxygenation. Representative Selected Recent Publications: Thomas A G, Marrett S, Saad Z S, Ruff D A, Martin A, Bandettini P A. Functional but not structural changes associate with learning: an exploration of longitudinal voxel based morphometry (VBM). NeuroImage 48, 117-125. 2009. Kriegeskorte N, Mur M, Bandettini PA. Representational similarity analysis - connecting the branches of systems neuroscience. Frontiers in Systems Neuroscience. doi:10.3389/neuro.06.004.2008. 2008. Kriegeskorte N, Mur M, Ruff D, Kiani R, Bodurka J, Esteky H, Tanaka K, Bandettini P.Matching categorical object representations in inferotemporal cortex of man and monkey. Neuron 60, 1-16. 2008. Kriegeskorte N, Bandettini P A. Analyzing for information, not activation, to exploit high-resolution fMRI, NeuroImage, 38, 649-662. 2007. Murphy K, Bodurka J, Bandettini P A. How long to scan? The relationship between fMRI temporal signal to noise and the necessary scan duration. NeuroImage, 34, 565-574. 2007. Bodurka J, Ye F, Petridou N, Murphy K, Bandettini P A. Mapping the MRI voxel volume in which thermal noise matches physiological noise – implications for fMRI. NeuroImage, 34, 542-549. 2007. (View PDF) Birn R M, Diamond J B, Smith M A, Bandettini P A. Separating respiratory variation-related fluctuations from neuronal activity-related fluctuations in fMRI, NeuroImage 31, 1536-1548. 2006. (View PDF) Address: Peter A. Bandettini Section on Functional Imaging Methods Laboratory of Brain and Cognition, NIMH Building 10, Room 1D80 10 Center Drive, MSC 1148 Bethesda, MD 20892-1148 Phone: (301) 402-1333 (office) (240) 938-1610 (mobile) Email Dr. Bandettini Fax: (301) 402-1370 Lab Web Site: http://fim.nimh.nih.gov/   Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.