| | Staff Scientists and Clinicians
| Fabrice G Siméon PhD |
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Dr. Fabrice G. Siméon is a Staff Scientist within the PET Radiopharmaceutical Sciences Section (PRSS) of the Molecular Imaging Branch (MIB). He obtained his PhD degree in the Department of Hybrid Materials and Rapid Syntheses from the University of Caen, (France). He was an Engineer Chemist in the Department of Sciences of Life for the French Atomic Energy Commission (CEA), Caen, before joining the MIB as a Visiting Fellow in 2003 where he became a Staff Scientist in January 2008. |
| Research Interests |
| Dr. Siméon’s research at the MIB is focused on the discovery, synthesis and radiolabeling of new radioligands for imaging pecific brain proteins in living human subjects with positron emisision tomography (PET). Since joining the MIB, he has taken part in the development of new PET radioligands for imaging either metabotropic glutamate receptor subtype 5 receptors (mGluR5), or translocator protein (TSPO, formerly known as peripheral benzodiazepine receptors). mGlur5 are possibly involved in schizophrenia, pain, anxiety and Alzheimer’s disease. Elevated TSPO levels are markers of inflammation). His research has lead to successful ligands/radioligands, including one described as "Molecule of The Month" in Current Topics in Medicinal Chemistry in 2007 (vol. 7, 1541). He also pursued other projects aimed at advancing the methodology of PET radiochemistry,
including for example the direct radiofluorination of thiazoles. |
| Representative Selected Recent Publications: |
- Siméon FG, Wendahl MT, Pike VW: Efficient and regioselective halogenations of 2-amino-1,3-thiazoles with copper salts. J. Org. Chem., 74: 2578-2581, 2009.
- Fujimura Y, Zoghbi SS, Siméon FG, Taku A, Pike VW, Innis RB, Fujita M: Quantification of peripheral benzodiazepine (18 kDa) receptors in human brain with positron emission tomography and a novel radioligand, 18F-PBR06. J. Nucl. Med., 50: 1047-1053, 2009.
- Briard E, Zoghbi SS, Siméon FG, Imaizumi M, Gourley J, Shetty HU, Lu S, Fujita M, Innis RB, Pike VW: Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET. J. Med. Chem., 52: 688-699, 2009.
- Shetty HU, Zoghbi SS, Siméon FG, Liow J-S, Brown AK, Kannan P, Innis RB, Pike VW: Radiodefluorination of 3-fluoro-5-(2-(2-[18F](fluoromethyl) thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subtype-5 receptors with positron emission tomography, occurs by glutathionylation in rat brain. J. Pharmacol. Exper. Ther., 327: 727-735, 2008.
- Siméon FG, Brown AK, Zoghbi SS, Patterson VM, Innis RB, Pike VW: Synthesis and simple 18F-labeling of a high affinity 2 (fluoromethyl)thiazole derivative ([18F]SP203) as a radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with PET. J. Med. Chem., 50: 3256-3266, 2007.
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