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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Staff Scientists and Clinicians Stefano Marenco, M.D.   Dr. Marenco received his MD at the University of Genova, Italy. He then completed residency training in Clinical Neurophysiology at the University of Genova and in Psychiatry at the University of Maryland in Baltimore. Further training consisted in research fellowships at the NIMH, Clinical Brain Disorders Branch (1989-1991 and 1998-2004, under the mentorship of Daniel R. Weinberger, MD) and at Johns Hopkins University (1993-1994: with Dean F. Wong, MD, PhD). He is board certified in Psychiatry. He has been a Staff Clinician in the Genes, Cognition and Psychosis Program since 2004. Research Interests Dr. Marenco’s current interests and expertise center on the study of how genetic variation that predisposes to schizophrenia, impacts on MRI phenotypes, particularly proton spectroscopy and diffusion tensor imaging. He has expertise also in the field of neurodevelopmental risk factors for schizophrenia, the glutamate hypothesis of schizophrenia, classical conditioning, and positron emission tomography. Moreover, he has contributed to describing the phenotype of individuals with Williams syndrome with diffusion tensor imaging, in collaboration with Karen Berman, MD. Representative Selected Recent Publications: Stern, A. J., Savostyanova, A. A., Goldman, A., Barnett, A. S., van der Veen, J. W., Callicott, J. H., Mattay, V. S., Weinberger, D. R. and Marenco, S.: Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla. Biol Psychiatry, 64(10): 856-62, 2008. Nicodemus, K. K., Marenco, S., Batten, A. J., Vakkalanka, R., Egan, M. F., Straub, R. E. and Weinberger, D. R.: Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk. Mol. Psychiatry, 13(9): 873-7, 2008. Matsumoto, M., Straub, R. E., Marenco, S., Nicodemus, K. K., Matsumoto, S., Fujikawa, A., Miyoshi, S., Shobo, M., Takahashi, S., Yarimizu, J., Yuri, M., Hiramoto, M., Morita, S., Yokota, H., Sasayama, T., Terai, K., Yoshino, M., Miyake, A., Callicott, J. H., Egan, M. F., Meyer-Lindenberg, A., Kempf, L., Honea, R., Vakkalanka, R. K., Takasaki, J., Kamohara, M., Soga, T., Hiyama, H., Ishii, H., Matsuo, A., Nishimura, S., Matsuoka, N., Kobori, M., Matsushime, H., Katoh, M., Furuichi, K. and Weinberger, D. R: The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Proc Natl Acad Sci U S A , 105(16): 6133-8., 2008. Marenco, S., Siuta, M. A., Kippenhan, J. S., Grodofsky, S., Chang, W. L., Kohn, P., Mervis, C. B., Morris, C. A., Weinberger, D. R., Meyer-Lindenberg, A., Pierpaoli, C. and Berman, K. F.: Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Proc Natl Acad Sci U S A, 104(38): 15117-22, 2007. Marenco, S., Steele, S. U., Egan, M. F., Goldberg, T. E., Straub, R. E., Sharrief, A. Z. and Weinberger, D. R.: Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex. American Journal Of Psychiatry, 163(4): 740-742, 2006. Marenco, S., Carson, R. E., Berman, K. F., Herscovitch, P. and Weinberger, D. R.: Nicotine-induced dopamine release in primates measured with [11C]raclopride PET. Neuropsychopharmacolog , 29(2): 259-68, 2004. Address: Phone: 301-435-8964 Email Dr. Marenco Fax: 301-402-1370 Lab Web Site: http://intramural.nimh.nih.gov/gcap/     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Neurophysiology Imaging Facility Scientific and Statistical Computing Core Section on Instrumentation Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.