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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Staff Scientists and Clinicians Mary M. Herman, M.D. Dr. Herman is a Neuropathologist and Senior Staff Scientist in the Clinical Brain Disorders Branch of the DIRP, NIMH. She graduated from the University and Medical School at the University of Wisconsin in Madison, Wisconsin, and completed residencies in Pathology and Neuropathology at Yale and Stanford Universities. She was on the faculty of Stanford University for fifteen years, rising to Associate Professor of Pathology with tenure, followed by eleven years as Professor of Pathology and Co-Director of Neuropathology at the University of Virginia. Dr. Herman joined the NIMH in 1991 as a Special Expert in Neuropathology, followed by her present appointment in 1996. She is board-certified in Anatomical Pathology and Neuropathology. Dr. Herman has been a member of the Editorial Board of the Journal of Neuropathology on two occasions and is a member of numerous pathology societies as well as the Society of Biological Psychiatry and the Society for Neuroscience, among others. She has received the Merck Faculty Development Award from the Merck Foundation, a Research Career Development Award, and the Weil Award from the AANP. She has published over 200 scientific articles. Research Interests Dr. Herman is the Neuropathologist at the NIMH and collaborates with the Clinical Brain Disorders Branch. She will be the Neuropathologist for the proposed Neuropathology Core Facility in the DIRP, NIMH. Her research interests in schizophrenia encompass an evaluation of glial pathology and of COMT, growth factors, and the morphometric analysis of neuronal populations in the cerebrum and cerebellum. Selected Publications: Colantuoni, C., Hyde, T.M., Mitkus, S., Joseph, A., Sartorius, L., Aguirre, C., Creswell, J., Johnson, E., Deep-Soboslay, A., Herman, M.M., Lipska, B.K., Weinberger, D.R., and Kleinman, J.E.: Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex. Brain Struct. Funct., 213:255-271, 2008. (View PDF) Cai, L., Liow, J.-S., Zoghbi, S.S., Cuevas, J., Baetas, C., Hong, J., Shetty, H.U., Seneca, N.M., Brown, A.K., Gladding, R., Temme, S.S., Herman, M.M., Innis, R.B., and Pike, V.W: Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4′-N,N-dimethylamino) phenylimidazo[1,2-a] pyridines as radioligands for imaging β-amyloid plaques in Alzheimer’s Disease. J. Med. Chem., 51:148-158, 2008. (View PDF) Lipska, B.K., Peters, T., Hyde, T.M., Halim, N., Horowitz, C., Mitkus, S., Weickert, C.S., Matsumoto, M., Sawa, A., Straub, R.E., Vakkalanka, R., Herman, M.M., Weinberger, D.R., and Kleinman, J.E.: Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Hum. Mol. Genet., 15:1245-1258, 2006. (View PDF) Matsumoto, M., Weickert, C.S., Akil, M., Lipska, B.K., Hyde, T.M., Herman, M.M., Kleinman, J.E., and Weinberger, D.R.: Catechol O-methyl-transferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience, 116:127-137, 2003. (View PDF) Damadzic, R., Shuangshoti, S., Giblen, G., and Herman, M.M.: Neuritic pathology is lacking in the entorhinal cortex, subiculum, and hippocampus in middle-aged adults with schizophrenia, bipolar disorder or unipolar depression. Acta Neuropathol., 103:488-494, 2002. (View PDF) Damadzic, R., Bigelow, L.B., Krimer, L.S., Goldenson, D.A., Saunders, R.C., Kleinman, J.E., and Herman, M.M.: A quantitative immunohistochemical study of astrocytes in the entorhinal cortex in schizophrenia, bipolar disorder, and major depression: absence of significant astrogliosis. Brain Res. Bull., 55:611-618, 2001. (View PDF) Address: 49 Convent Drive Room B1B80, MSC 4425 Bethesda, MD 20892-4425 Phone: 301-480-0042 E-mail Dr. Herman Fax: 301-480-0023 Lab Web Site: http://cbdb.nimh.nih.gov/     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.