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DIVISION OF INTRAMURAL RESEARCH PROGRAMS
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 Staff Scientists and Clinicians

Monique Ernst, M.D., Ph.D.
Photo Not Available   Dr. Ernst is a Staff Clinician in the Section of Developmental and Affective Neuroscience (SDAN) of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. She completed medical school at the Pitie Salpetriere University in Paris, France, and the Ph.D. program in Neurophysiology; Nervous System and Behavior of the Jussieu University of Paris VI. She did residencies in adult psychiatry at Beth Israel Medical Center and in child psychiatry at Bellevue Hospital & New York Medical Center in New York. She is certified by the American Board of Psychiatry and Neurology in Psychiatry and by the American Board of Psychiatry and Neurology in Child and Adolescent Psychiatry.
Research Interests
Dr. Ernst’s research has focused on brain mechanisms involved in risk factors, pathogenesis, and treatment of pediatric neuropsychiatric disorders. Before joining NIMH in March 2001, her work was centered on children with autism, Lesch-Nyhan Disease, attention-deficit/hyperactivity disorder and substance abuse problems. As part of the Section of Developmental and Affective Neuroscience, she is now building a research program to examine in children genetic vulnerabilities for mood and anxiety disorders, and to map deficits in reward-related behaviors which play a role in mood disorders.

Her work is noted for studies of functional neuroimaging in children aimed at clarifying dopaminergic deficits in disorders involving dopamine abnormalities. She lately concentrated her work on reward-related mechanisms, using both positron emission tomography and functional magnetic resonance imaging.
Representative Selected Recent Publications:
  • Ernst M, Grant SJ, London ED, Contoreggi CS, Kimes AS, Spurgeon L.: Decision-Making in Behavior Disordered Adolescents and Adult Substance Abusers Am J Psychiatry (in press).
  • Ernst M, Bolla K, Mouratidis M, Contoreggi C, Matochik JA, Kurian V, Cadet J-L, Kimes AS, London ED.: Decision-making in a risk-taking task: a PET study. Neuropsychopharmacology 26, (5) 683-691. 2002.
  • Ernst M, Zametkin AJ, Matochik JA, Jons PH, and Cohen RM.: Presynaptic Dopaminergic Activity in ADHD Adults. A [Fluorine-18]Fluorodopa Positron Emission Tomographic Study. J Neuroscience, 18 (15): 5901-5907, 1998.
  • Ernst M, Zametkin AJ, Matochik JA, Pascualvaca D, Jons, P, Cohen RM: High midbrain DOPA decarboxylase activity in children with ADHD, Am J Psychiatry 156:1209-1215, 1999.
  • Ernst M, Zametkin AJ, Matochik JA, Pascualvaca D, Cohen RM. : Low medial prefrontal dopaminergic activity in autistic children. The Lancet, 350:638, 1997.
  • Ernst M., Zametkin A.J., Matochik J.A., Pascualvaca D., Jons P.H., Hardy K., Hankerson J.G., Doudet D.D., Cohen R.M.:(1996) Presynaptic dopaminergic deficits in Lesch-Nyhan Disease. New England Journal of Medicine, 334:1568-1604. 1996.

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This page was last updated January 13, 2011.


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