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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Staff Scientists and Clinicians Joseph H. Callicott, M.D.   Dr. Callicott is Chief of the Unit on Dynamic Imaging Genetics (UDIG) within Clinical Brain Disorders Branch of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. He received his B.A. the College of William and Mary and his M.D. from the University of Virginia School of Medicine. He completed his internship and two years of psychiatry residency in the University of Virginia Psychiatric Medicine Program at U.Va. He finished his last year of residence and a two year research fellowship within the Clinical Brain Disorders Branch at the St. Elizabeths campus of the NIMH. He is board certified in psychiatry. Dr. Callicott has been at the NIMH from 1994 to the present and published over 75 papers on information processing deficits in schizophrenia as measured by functional magnetic resonance imaging. His initial studies focused on prefrontal information processing inefficiency in patients with schizophrenia and their unaffected siblings. More recently, he has expanded his work to include genetic variants associated with reduced information processing efficiency and with increased risk for schizophrenia. Research Interests Dr. Callicott’s published one of the first reports to demonstrate the physiological fMRI signature of inefficient information processing in patients with schizophrenia (so-called ‘hyperfrontality’) and helped formulate a theoretical model of non-overlapping inverted-U shaped curves separating patients and controls thus unifying findings of both reduced and increased prefrontal activity in patients. His group reported some of the earliest familial intermediate neuroimaging phenotypes (e.g., reduced hippocampal NAA measures and increased prefrontal inefficiency) by studying unaffected siblings as part of the NIMH Genetic Study of Schizophrenia (the “CBDB Sibling Study”). As the lab transitioned to genetic research, Dr. Callicott broadened his focus to those genetic polymorphisms related to variability in these phenotypes (e.g. DISC1 in hippocampus and COMT in the prefrontal cortex). His group has implemented an array of prefrontal tasks with which they hope to further lend specificity to neuronal dysfunction introduced by candidate genes and pathways. He has active collaborations with labs in the U.S., Italy, and Norway. Representative Selected Recent Publications: Callicott JH, Straub RE, Pezawas L, Egan MF, Mattay VS, Hariri AR, Verchinksi BA, Meyer-Lindenberg A, Balkissoon R, Kolachana B, Goldberg TE, Weinberger DR. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci USA, 102: 8627–8632, 2005. Egan MF, Callicott JH*, Kojima M*, Goldberg TE*, Kolachana BF, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 2003. *(These authors contributed equally). Callicott JH, Egan MF, Mattay VS, Bertolino A, Bone A, Verchinski BA, Weinberger DR.: Physiological dysfunction of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psych, 160:709-719, 2003. Callicott JH, Bertolino A, Mattay VS, Langheim FJ, Duyn J, Coppola R, Goldberg TE, Weinberger DR: Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia: revisited. Cereb Cortex, 10(11):1078-1092, 2000. Callicott JH, Bertolino A, Egan MF, Mattay VS, Langheim FJ, Weinberger DR.: Selective relationship between prefrontal N-acetylaspartate measures and negative symptoms in schizophrenia. Am J Psychiatry, 157(10):1646-1651, 2000. Callicott JH, Mattay VS, Bertolino A, Finn K, Coppola R, Frank JA, Goldberg TE, Weinberger DR. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb Cortex, 9(1):20-26, 1999. Address: Joseph H. Callicott, M.D. Chief, Unit on Cognition and Psychosis Program 10 Center Drive Room 3C-117 Bethesda, MD 20892 Phone: 301-402-3081 Email Dr. Callicott Fax: 301-451-5148 Lab Web Site: http://udig.nimh.nih.gov/     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Neurophysiology Imaging Facility Scientific and Statistical Computing Core Section on Instrumentation Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.