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Section on Developmental Genetic
Epidemiology Website
Kathleen R. Merikangas, Ph.D.
This program applies the
tools of epidemiology and genetics to identify risk factors for mood and
anxiety disorders, and their association with other psychiatric and medical
disorders. Disciplinary representation within this section include:
epidemiology, clinical psychology, developmental psychology, genetic
epidemiology, psychiatry, and biostatistics. The major research goals are:
- To apply the family study design to identify
heritable components of psychiatric disorders and sources of comorbidity
with other psychiatric and medical disorders
- To study mechanisms for comorbidity between mood
and anxiety disorders with other psychiatric disorders (ie., substance
abuse) and medical disorders (ie.,
migraine)
- To identify early manifestations of
psychopathology by studying prospectively offspring of parents with
psychiatric disorders using comprehensive domains of assessment with
particular focus on the emergence of sex differences across the adolescent
and early adult transitions
- To conduct pilot studies of the components of
prevention programs for mood and anxiety disorders in youth
- To develop and apply study designs and
statistical methods to identify gene – environment interaction using
studies of half-siblings and step-siblings, offspring of twins and migrant
studies
Samples for the programs in
this Section include: Clinical samples of subjects with anxiety and affective
disorders and their relatives and spouses; Population based samples of children
and adolescents identified through local schools; Population based samples of
adults.
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