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Background. Approximately one-third of patients with Parkinson disease develop dementia. The dementia may be caused by a loss of the function of the neurotransmitter acetylcholine in cortex. We measured the levels of a particular acetylcholine receptor in cortex, the nicotinic acetylcholine receptor (nAChR) and found widespread loss in patients with Parkinson disease.
Legend. Brain areas with a significant decrease of [123I]5-I-A-85380 distribution volume (V) in Parkinson’s disease patients detected with a two sample t-test in SPM2. Areas with a significant decrease are displayed in the glass brain (left) and on transverse and coronal slices through thalamus of an MR image of a control subject (middle). Corresponding MR images without superimposition are shown on the right. Highlighted areas showed p less than 0.05 false discovery rate, which was corrected for multiple comparisons. The area also showed cluster-level corrected p < 0.001. The color bar shows T values with the maximum value of 4.96. Note that the glass brain view displays decreases in the entire brain superimposed to anterior-posterior (left top) or top-bottom (left bottom) views while the MR images with the superimposition display decreases on single slices.
Reference. M. Fujita, M. Ichise, S.S. Zoghbi, J.-S. Liow, S. Ghose, D.C. Vines, J. Sangare, J.Q. Lu, V.L. Cropley, H. Iida, K.M. Kim,, R.M. Cohen, W. Bara-Jimenez, B. Ravina, and R.B. Innis. Widespread decrease of nicotinic acetylcholine receptors in Parkinson’s disease. Ann.Neurol., 59: 174-177, 2006.
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