The mission of this unit is to determine the human genetic variation that contributes to the risk for mood and anxiety disorders such as bipolar disorder and panic disorder, so that better methods of diagnosis and treatment can be developed. They recruit families with multiple cases of mood disorder for use in genetic mapping studies. Volunteers are asked to provide a blood sample and undergo a psychiatric interview, usually over the telephone.

      Current research priorities include genome-wide linkage mapping of bipolar susceptibility genes, fine-mapping bipolar disorder susceptibility loci on chromosomes 6q, 13q, 18q, and 22q; identification of clinical features that define highly familial clinical subtypes of mood disorders; the elucidation of parent-of-origin effects in the familial transmission of mood disorders; and candidate gene studies. They also study patterns of linkage disequilibrium and "haplotype blocks" in the human genome.

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