| Robert B. Innis, M.D., Ph.D.
Dr.
Robert Innis is Chief of the Molecular Imaging Branch at the National Institute
of Mental Health. He directs a research
group which performs in vivo neurochemical imaging, primarily with PET
(positron emission tomography) and with an emphasis on targets relevant to
neuropsychiatric disorders.
Dr.
Innis graduated from Yale College (1974) and then received his MD (1978) and
pharmacology PhD (1981) degrees from Johns Hopkins. After psychiatry residency
training at Yale, he joined the faculty in 1984 and rose to the rank of
Professor of Psychiatry and Pharmacology.
Because
PET was not available at Yale in the 1980s, Dr. Innis used SPECT for studies of
receptors in the brain. His work on benzodiazepine receptor imaging clearly confirmed
that SPECT was capable of quantitative measurements, with validation comparable to
that in PET. His SPECT work expanded to include other neurotransmitter systems,
including dopamine, serotonin, GABA, and acetylcholine.
Dr. Innis has developed new
radiotracers, including probes for the dopamine transporter. In fact, the dopamine
transporter is a biological marker for Parkinson's disease – and SPECT imaging of the
dopamine transporter was recently approved in several European countries to aid in
the early diagnosis of Parkinson's disease.
Dr. Innis moved to NIMH in 2001
to direct a new Molecular Imaging Branch. Major goals of this new laboratory include
the development of new PET tracers and the integration of PET with other
neuroimaging methodologies, especially MRS (magnetic resonance spectroscopy). |