2 Research Method Development

2.9 Solid phase radiochemistry

In collaboration with Dr. S. Lepore (Florida Atlantic U.) we are developing novel arylsulfonate-based nucleophilic assisted leaving groups (NALGs) that in non-radioactive work show remarkable rateenhancement in nucleophilic displacement reactions.⁵⁶ This approach should be useful for the development of efficient resin-supported [¹⁸F]fluoridation with the advantage of ease of radioactive product separation (Figure 4).