1. CHUN J.-H., LU S., PIKE V.W., Rapid and Efficient Radiosyntheses of meta-Substituted [¹⁸F]Fluoroarenes from [¹⁸F]Fluoride Ion and Diaryliodonium Tosylates within a Microreactor, Eur. J. Org. Chem. 2011, 4439–4447. Download PDF

2. PIKE V. W., TALIANI S., LOHITH T. G., OWEN D. R. J., PUGLIESI I., DA POZZO E., HONG J., ZOGHBI S. S., GUNN R. N., PARKER C. A., RABINER E. A., FUJITA M., INNIS R. B., MARTINI C., DA SETTIMO F., Evaluation of Novel N¹-Methyl-2-phenylindol-3-ylglyoxylamides as a New Chemotype of 18 kDa Translocator Protein-Selective Ligand Suitable for the Development of Positron Emission Tomography Radioligands, J. Med. Chem. 2011, 54, 366–373. Download PDF

3. PIKE V. W., RASH K. S., CHEN Z., PEDREGAL C., STATNICK M. A., KIMURA Y., HONG J., ZOGHBI S. S., FUJITA M., TOLEDO M. A., DIAZ N., GACKENHEIMER S. L., TAUSCHER J. T., BARTH V. N., INNIS R. B., Synthesis and Evaluation of Radioligands for Imaging Brain Nociceptin/Orphanin FQ Peptide (NOP) Receptors with Positron Emission Tomography, J. Med. Chem. 2011, 54, 2687–2700. Download PDF

4. DONOHUE S. R., DANNALS R. F., HALLDIN C., PIKE V. W., N-(4-Cyanotetrahydro-2H-pyran-4-yl) and N-(1-Cyanocyclohexyl) Derivatives of 1,5-Diarylpyrazole-3-carboxamides Showing High Affinity for 18 kDa Translocator Protein and/or Cannabinoid Receptors, J. Med. Chem. 2011, 54, 2961–2970. Download PDF

5. SIMEON F. G., WENDAHL M. T., PIKE V. W., Syntheses of 2-Amino and 2-Halothiazole Derivatives as High-Affinity Metabotropic Glutamate Receptor Subtype 5 Ligands and Potential Radioligands for in Vivo Imaging, J. Med. Chem. 2011, 54, 901–908. Download PDF

6. OWEN D. R. J., GUNN R. N., RABINER E. A., BENNACEF I., FUJITA M., KREISL W. C., INNIS R. B., PIKE V. W., REYNOLDS R., MATTHEWS P. M., PARKER C. A., Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands, J. Nucl. Med. 2011, 52, 24–32. Download PDF

7. ZANOTTI-FREGONARA P. ZOGHBI S. S., LIOW J.-S., LUONG E., BOELLAARD R., GLADDING R. L., PIKE V. W., INNIS R. B., FUJITA M., Kinetic analysis in human brain of [¹¹C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: A retest study and use of an image-derived input function, NeuroImage 2011, 54, 1903–1909. Download PDF

8. DICKSTEIN L. P., ZOGHBI S. S., FUJIMURA Y., IMAIZUMI M., ZHANG Y., PIKE V. W., INNIS R. B., FUJITA M., Comparison of ¹⁸F- and ¹¹C-labeled aryloxyanilide analogs to measure translocator protein in human brain using positron emission tomography, Eur. J. Nucl. Med. Mol. Imaging 2011, 38, 352–357. Download PDF

9. KANNANA P., BRIMACOMBE K. R., KREISL W. C., LIOW J.-S., ZOGHBI S. S., TELU S., ZHANG Y., PIKE V. W., HALLDIN C., GOTTESMAN M. M., INNIS R. B., HALL M. D., Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET, PNAS 2011, 108 ( 6), 2593–2598. Download PDF

10. ZANOTTI-FREGONARA P., LIOW J.-S., FUJITA M., DUSCH E., ZOGHBI S. S., LUONG E., BOELLAARD R., PIKE V. W., COMTAT C., INNIS R. B., Image-Derived Input Function for Human Brain Using High Resolution PET Imaging with [¹¹C](R)-rolipram and [¹¹C]PBR28, PLoS ONE 2011, 6 (2), e17056. Download PDF

11. KANNAN P., TELU S., SHUKLA S., AMBUDKAR S. V., PIKE V. W., HALLDIN C., GOTTESMAN M. M., INNIS R. B., HALL M. D., The "Specific" P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2), ACS Chem. Neurosci. 2011, 2, 82–89. Download PDF

12. TELU S., CHUN J.-H., SIMEON F. G., LU S., PIKE V. W., Syntheses of mGluR5 PET radioligands through the radiofluorination of diaryliodonium tosylates, Org. Biomol. Chem. 2011, in press. Download PDF

13. KIMURA Y., FUJITA M., HONG J., LOHITH T. G., GLADDING R. L., ZOGHBI S. S., TAUSCHER J. A., GOEBL N., RASH K.S., CHEN Z., PEDREGAL C., BARTH V. N., PIKE V. W., INNIS R. B., Brain and whole-body imaging in rhesus monkeys of ¹¹C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide (NOP) receptors, J. Nucl. Med. 2011, 52, 1638-1645. Download PDF

14. HINES C. S., LIOW J.-S., ZANOTTI-FREGONARA P., HIRVONEN J., MORSE C., PIKE V. W., INNIS R. B., Human biodistribution and dosimetry of ¹¹C-CUMI-101, an agonist radioligand for serotonin-1A receptors in brain, Plos One 2011, 6, e25309. Download PDF

15. OH U., FUJITA M., IKONOMIDOU V. N., EVANGELOU I. E., MATSUURA E., HARBERTS E., OHAYON J., PIKE V. W., ZHANG Y., ZOGHBI S. S., INNIS R. B., JACOBSON S., Translocator protein PET imaging for glial activation in multiple sclerosis, J. Neuroimmune Pharmacol. 2011, 6, 354-361. Download PDF

16. HALL M.D., PIKE V.W., Avoiding barriers to PET radioligand development: cellular assays of brain efflux transporters, J. Nucl. Med. 2011, 52, 338-340. Download PDF

17. CAI L. Z, YANG D. J, SUN, Z. H., TAO X. C, CAI L. S., PIKE V. W. Palladium-catalyzed coupling between aryl halides and trimethylsilylacetylene assisted by dimethylaminotrimethyltin, Chinese J. Chem. 2011, 29, 1059-1062. Download PDF