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1. CHUN J.-H., LU S., LEE Y.-S. & PIKE V.W. Fast and high-yield micro-reactor syntheses of ortho-substituted [18F]fluoroarenes from reactions of [18F]fluoride ion with diaryliodonium salts. J. Org. Chem. (2010) 75, 3332-3338. Download PDF
2. LU S., LIOW J.-S., ZOGHBI S.S., HONG J., INNIS R.B. & PIKE V.W. Evaluation of [11C]S14506 and [18F]S14506 in rat and monkey as agonist PET radioligands for brain 5-HT1A receptors. Curr. Radiopharm. (2010) 3, 9-18. Download PDF
3. LEE Y-S., HODOSEK M., CHUN J.-H. & PIKE V.W. Conformational structure and energetics of 2-methylphenyl(2'-methoxyphenyl)-iodonium chloride: evidence for formation of clusters. Chemistry – A Eur. Journal. (2010) 16, 10418-10423. Download PDF
4. LU S., HONG J., ITOH T., FUJITA M., INNIS R.B. & PIKE V.W. [carbonyl-11C]Benzyl acetate: automated radiosynthesis via Pd mediated [11C]carbon monoxide chemistry and PET measurement of brain uptake in monkey. J. Label Compd. Radiopharm. (2010) 53, 548-551. Download PDF
5. ITOH T., ABE K., HONG J., INOUE O., PIKE V.W., INNIS R.B. & FUJITA M. Effects of cAMP-dependent protein kinase activator and inhibitor on in vivo rolipram binding to phosphodiesterase 4 in conscious rats. Synapse (2010) 64, 172-176. Download PDF
6. FUJIMURA Y., KIMURA Y., SIMÉON F.G., DICKSTEIN L.P., PIKE V.W., INNIS R.B. & FUJITA M. Biodistribution and radiation dosimetry in humans of a new PET ligand, 18F-PBR06, to image translocator protein (18 kDa). J. Nucl. Med. (2010) 51, 145-149. Download PDF
7. TERRY G.E., HIRVONEN J., LIOW J.-S., ZOGHBI S.S., GLADDING R., TAUSCHER J.T., SCHAUS J.M., PHEBUS L., FELDER C.C., MORSE C.L., DONOHUE S.R., PIKE V.W., HALLDIN C. & INNIS R.B. Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using 18F-labeled inverse agonist radioligands. J. Nucl. Med. (2010) 51, 112-120. Download PDF
8. KREISL W.C., FUJITA M., FUJIMURA Y., KIMURA N., JENKO K.J., KANNAN P., HONG J., MORSE C.L., ZOGHBI S.S., GLADDING R.L., JACOBSON S., OH U., PIKE V.W. & INNIS R.B. Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission tomographic imaging of this inflammation biomarker. NeuroImage (2010) 49, 2924-2932. . Download PDF
9. SENECA N., ZOGHBI S.S., SHETTY H.U., TUAN E., KANNAN P., TAKU A., INNIS R.B. & PIKE V.W. Effects of ketoconazole, on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice. Nucl. Med. Biol. (2010) 37, 335-345.. Download PDF
10. KREISL W.C., LIOW J.-S., KIMURA N., SENECA N., ZOGHBI S.S., MORSE C.L., HERSCOVITCH P., PIKE V.W. & INNIS R.B. P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide. J. Nucl. Med. (2010) 51, 559-566. Download PDF
11. SKINBJERG M., LIOW J.-S., SENECA N., HONG J., LU S., THORSELL A., HEILIG M., PIKE V.W., HALLDIN C., SIBLEY D.R. & INNIS R.B. Dopamine D2 receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a mouse model incapable of internalization. NeuroImage (2010) 50, 1402-1407. Download PDF
12. LAW M.P., WAGNER S., KOPKA K., RENNER C., PIKE V.W., SCHOBER O. & SCHÄFERS M. Preclinical evaluation of an 18F-labelled β1-adrenoceptor selective radioligand based on ICI 89,406. Nucl. Med. Biol. (2010) 37, 517-526. Download PDF
13. KANNAN P., BRIMACOMBE K.R., ZOGHBI S.S., LIOW J.-S., MORSE C., TAKU A.K., PIKE V.W., HALLDIN C., INNIS R.B., GOTTESMAN M.M. & HALL M.D. N desmethyl-Loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier. Drug Metab. Disposition. (2010) 38, 917-922. Download PDF
14. HIRVONEN J., TERRY G. E., HALLDIN C., PIKE V. W., & INNIS R. B. Approaches to quantify radioligands that wash out slowly from target organs. Eur. J. Nucl. Med. Mol. Imaging (2010) 37, 917–919. Download PDF
15. SKINBJERG M., SENECA N., LIOW J.-S., HONG J., WEINSHENKER D., PIKE V.W., HALLDIN C., SIBLEY D.R. & INNIS R.B. Dopamine β-hydroxylase-deficient mice have normal densities of D2 dopamine receptors in the high affinity state based on in vivo PET imaging and in vitro radioligand binding. Synapse (2010) 64, 699-703. Download PDF
16. OZAKI H., ZOGHBI S.S., HONG J., VERMA A., PIKE V.W., INNIS R.B. & FUJITA M. In vivo binding of protoporphyrin IX to rat translocator protein imaged with positron emission tomography. Synapse (2010) 64, 649-653. Download PDF
17. TERRY G.E., HIRVONEN J., LIOW J.-S., SENECA N., TAUSCHER J.T., SCHAUS J.M., PHEBUS L., FELDER C.C., MORSE C.L., PIKE V.W., HALLDIN C. & INNIS R.B. Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography. Eur. J. Nucl. Med. Mol. Imaging (2010) 37, 1499-1506. Download PDF
18. KIMURA Y., SIMÉON F.G., HATAZAWA J., MOZLEY P. D., PIKE V.W., INNIS R.B. & FUJITA M. Biodistribution and radiation dosimetry of a positron emission tomography ligand, 18F-SP203, to image metabotropic glutamate subtype 5 (mGluR5) receptor in humans. Eur. J. Nucl. Med. Mol. Imaging (2010) 37, 1943-1949. Download PDF
19. SIMEON F.B., WENDAHL M. & PIKE V. W. The [18F]2-fluoro-1,3-thiazolyl moiety—an easily-accessible structural motif for prospective molecular imaging radiotracers. Tetrahedron Lett. (2010) 51, 6034-6036. Download PDF
20. XU R., HONG J., MORSE C.L. & PIKE V.W. Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. J. Med. Chem. (2010) 53, 7035-7047. Download PDF
21. LU S.Y.& PIKE V.W. Synthesis of [18F]xenon difluoride as a radiolabeling reagent from [18F]fluoride ion in a micro-reactor and at production scale. J. Fluorine Chem. (2010) 131, 1032-1038. Download PDF
22. PENG Y.Y., ZENG Y.Y., QIU G.Y.S., CAI L.S. & PIKE V.W. A convenient one-pot procedure for the synthesis of 2-aryl quinazolines using active MnO2 as oxidant. J. Heterocyclic Chem. (2010) 47, 1240-1245 Download PDF.
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