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1. CAI L., LU, S.Y. & PIKE V.W. The chemistry of [18F]fluoride ion. Eur. J. Org. Chem. (2008) 17, 2853-2873. (Invited review featured on journal cover). Download PDF
2. FUJITA M., IMAIZUMI M., ZOGHBI S.S., FUJIMURA Y., FARRIS A.G., SUHARA T., HONG J., PIKE V.W. & INNIS R.B. Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation. NeuroImage (2008), 40, 43-52. Download PDF
3. BRIARD E., ZOGHBI S.S., IMAIZUMI M., GOURLEY J.P., SHETTY H.U., HONG J., CROPLEY V., FUJITA M., INNIS R.B. & PIKE V.W. Synthesis and evaluation of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J. Med. Chem. (2008) 51, 17-30. Download PDF
4. CAI L., LIOW J.-S., ZOGHBI S.S., CUEVAS J., BAETAS C., HONG J., SHETTY H.U., SENECA N.M., BROWN A.K., GLADDING R., TEMME S.S., HERMAN M.M., INNIS R.B. & PIKE V.W. Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4’-N,N-dimethyamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging β-amyloid plaques in Alzheimer’s disease. J. Med. Chem. (2008) 51, 148-158. Download PDF
5. YASUNO F., BROWN A.K., ZOGHBI S.S., KRUSHISKI J.H., CHERNET E., TAUSCHER J., SCHAUS J., PHEBUS L., CHESTERFIELD A.K., FELDER C., GLADDING R.L., HONG J., HALLDIN C., PIKE V.W. & INNIS R.B. The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain. Neuropsychopharmacology (2008) 33, 259-269. Download PDF
6. LAW M.P., WAGNER S., KOPKA K., PIKE V.W., SCHÖBER O. & SCHÄFERS M. Are [O–methyl–11C]derivatives of ICI 89,406 ß1 adrenoceptor selective radioligands suitable for PET? Eur J. Nucl. Med & Mol. Imaging. (2008) 35, 174-185. Download PDF
7. IMAIZUMI M., BRIARD E.; ZOGHBI S.S., GOURLEY J.P., HONG J., FUJIMURA Y., PIKE V.W., INNIS R.B. & FUJITA M. Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors. NeuroImage (2008) 39, 1289-1298. Download PDF
8. PIKE V.W., LU S.Y., HONG J., MUSACHIO J.L. & MCCARRON J.A. Alternative methods for making [11C]amides - application to the preparation of 5-HT1A receptor radioligands. IAEA. Proceedings of the International Symposium on Trends in Radiopharmaceuticals (2008) 2, 147-159. Download PDF
9. CROPLEY V.L., INNIS R.B., NATHAN P.J., BROWN A.K., SANGARE J.L., LERNER A., RYU Y.H., SPRAGUE K.E., PIKE V.W., & FUJITA M. Small effect of dopamine release and no effect of dopamine depletion on [18F]-fallypride binding in healthy humans. Synapse (2008) 62, 399-408. Download PDF
10. ZOGHBI S.S., LIOW J.-S., YASUNO F., HONG, J., TUAN E., LAZAROVA N., GLADDING R.L., PIKE V.W. & INNIS R.B. 11C-Loperamide and its N-desmethyl radiometabolite are avid substrates for brain P-glycoprotein efflux. J. Nucl. Med. (2008) 49, 649-656. Download PDF
11. HE T., TAO X., WU X., CAI L. & PIKE V.W. Acetylation of N-heteroaryl bromides via PdCl2/(o-tolyl)3P catalyzed Heck reactions. Synthesis (2008) 6, 887-890. Download PDF
12. DONOHUE S., HALLDIN C., SCHOU M., HONG J., PHEBUS L., CHERNET E., HITCHCOCK, S.A., GARDINIER K.M., RULEY K.M., KRUSHINSKI J.H., SCHAUS J. & PIKE V.W. Radiolabeling of a high potency cannabinoid subtype-1 receptor ligand, N (4-fluoro-benzyl)-4-(3-(piperidin-1-yl-indole-1-sulfonyl)benzamide (PipISB), with carbon-11 or fluorine-18. J. Label. Compd. Radiopharm. (2008) 51, 146-152. Download PDF
13. LEE Y.-S., PIKE V.W. & HODOSCEK M. Identification of the transition states in the inversion of 1,4-benzodiazepines with the ab-initio replica path method. J. Phys. Chem. A. (2008) 112, 1604-1611. Download PDF
14. DONOHUE S., ZOGHBI S.S., YASUNO S., TERRY G., GOURLEY P., INNIS R.B., HALLDIN C. & PIKE V.W. Radiosynthesis and evaluation in monkey of three 11C-labeled 1,5–diarylpyrazoles as high affinity candidate PET radioligands for cannabinoid subtype-1 receptors in brain. Current Radiopharmaceuticals (2008) 1, 93-102.
15. SPRAGUE D.R., FUJITA M., RYU Y.H., LIOW J.-S., PIKE V.W. & INNIS R.B. Whole Body distribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [11C](R)-rolipram: comparison of 2 dimensional planar, bisected, and quadrasected image analyses. Nucl. Med. Biol. (2008) 35, 493-500. Download PDF
16. TERRY G., LIOW J.-S., CHERNET E., ZOGHBI S.S., PHEBUS L., FELDER C., TAUSCHER J., SCHAUS J.M., PIKE V.W., HALLDIN C. & INNIS R.B. Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents. NeuroImage (2008) 41, 690-698.Download PDF
17. DONOHUE S.R, HALLDIN C. & PIKE V.W. A facile and regioselective synthesis of rimonabant through an enamine-directed 1,3–dipolar cycloaddition. Tetrahedron Lett. (2008) 49, 2789-2791. Download PDF
18. CROPLEY V.L., FUJITA M., BARA-JIMENEZ W., BROWN A.K., ZHANG X.-Y., SANGARE J., HERSCOVITCH P., PIKE V.W., HALLETT M., NATHAN P.J. &. INNIS R.B. Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPA. Psychiatry Research, Neuroimaging (2008) 163, 171-182. Download PDF
19. SENECA N., SKINBJERG M., ZOGHBI S.S., LIOW J.-S., GLADDING R.L., HONG J., KANNAN, TUAN E., SIBLEY D.R., HALLDIN C., PIKE V.W. & INNIS R.B. Kinetic brain analysis and whole-body imaging in monkey of [11C]MNPA, a dopamine agonist radioligand. Synapse (2008) 62, 700-709. Download PDF
20. SENECA N., ZOGHBI S.S., SKINBJERG M., LIOW J.-S., HONG J., SIBLEY D.R., PIKE V.W., HALLDIN C. & INNIS R.B. Occupancy of dopamine D2/3 receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [11C]MNPA. Synapse (2008) 62, 756-763. Download PDF
21. DONOHUE S.R., PIKE V.W., FINNEMA S.J., TRUONG P., ANDERSSON J., GULYÁS B., HALLDIN C. Discovery and labeling of high affinity 3,4-diarylpyrazolines as candidate radioligands for in vivo imaging of cannabinoid subtype-1 (CB1) receptors. J. Med. Chem. (2008) 51, 5608-5616. Download PDF
22. DONOHUE S.R., KRUSHINSKI J., PIKE V.W., CHERNET E., PHEBUS L., CHESTERFIELD A., FELDER C., HALLDIN C. & SCHAUS J. Synthesis, ex vivo evaluation and radiolabeling of potent 1,5-diphenyl-pyrrolidin-2-one cannabinoid subtype-1 (CB1) receptor ligands as candidates for in vivo imaging. J. Med. Chem. (2008) 51, 5833-5842. Download PDF
23. LAZAROVA N., ZOGHBI S.S. HONG J., SENECA N., TUAN E.; GLADDING R.L., LIOW J.-S, TAKU A., INNIS R.B. & PIKE V.W. Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. J. Med. Chem. (2008) 51, 6034-6043. Download PDF
24. SHETTY H.U., ZOGHBI S.S., SIMÉON F.G., LIOW J.S., BROWN A.K., KANNAN P., INNIS R.B. & PIKE V.W. 3-Fluoro-5-(2-(2-([18F]fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain mGluR5 in vivo, is defluorinated by glutathionylation in rat brain. J. Pharmacol. Exp. Therapeutics (2008) 327, 727-735. Download PDF
25. BROWN A.K., KIMURA Y., ZOGHBI S.S., SIMÉON F.G., LIOW J.-S., KREISL W.C., TAKU A., FUJITA M., PIKE V.W. & INNIS R.B. Metabotropic glutamate subtype-5 (mGluR5) receptors quantified in human brain with a novel radioligand for positron emission tomography. J. Nucl. Med. (2008) 49, 2042-2048. Download PDF
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