Building 35, Room 1C913, Bethesda, MD 20892-3724 Mission Statement Our group uses the tools of modern neuroanatomy to define and map out regulatory events that occur in animals when they respond to immune challenges, drug administration, emotional challenges, or stress. Responsive brain structures and cell types are identified by in situ hybridization histochemistry and immunohistochemistry. We are currently studying novel mechanisms by which immune molecules and transcription factors are active in the brain, using several in vivo paradigms. Approaches used include histochemical mapping of responsive genes and proteins in brain following central and peripheral administration of inflammatory agents, DNA microarray analysis of immune-related gene induction in brain following physiological challenge, viral vector-based delivery of DNA constructs to limbic system targets, and characterization of behavioral alterations in transgenic knockout mice with altered transcription factor signaling. Our recent work focuses on the role of NF-kappaB signaling the brain, particularly within emotional circuitry and in response to pathologic challenges. Current Area of Research Recent Areas of Research Personnel Cover Gallery Go to Neuroscience@NIH Return to NIMH Home Page Return to NIMH Intramural Research Program Updated April 25, 2008