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Jamie Ross

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Name: Jaime M. Ross
Nationality: United States
Educational background: Bachelor of Science from St. Lawrence University; Major: Neuroscience with concentration in Chemistry; Minor: Fine Arts.
Mentors: Barry J. Hoffer M.D., Ph.D. (NIH) and Lars Olson Ph.D. (KI)
Area of study: How mtDNA mutations can lead to aging and age-related disorders/diseases of the CNS
Current location: Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden
Research interests: mitochondrial dysfunction, neuroenergetics, neurodegenerative diseases

Contact information:
Karolinska Institutet
Department of Neuroscience
Retzius väg 8
171 77 Stockholm
Sweden

National Institute on Drug Abuse
Biomedical Research Center
251 Bayview Blvd
Baltimore, MD 21224
USA

rossja@nida.nih.gov or Jaime.Ross@ki.se
+1 (518) 632-1100 (US online number)
+46 8524.87051 (Sweden lab)

Recent honors and awards (2006 – Present):
NeurOnLine Champion: Neuroscience of Aging Community, Society for Neuroscience, 2011 – Present
NIH Pre-Doctoral Intramural Research Training Award (IRTA) Fellowship, NIDA, 2006 - Present
NIH Fellows Award for Research Excellence (FARE) recipient, 2010, 2011
Karolinska Institutet Travel Award, 2009, 2010, 2011
EU 6th Framework Program MiMage "Mitochondria in Ageing and Age-related Disease" Fellowship, 2009
Swiss Society for Neuroscience Fellowship, 2008
EU 6th Framework Program "PROUST – The temporal dimension in functional genomics," Fellowship, 2008
NIH Post-Baccalaureate Intramural Research Training Award (IRTA) Fellowship, NHLBI, 2005 - 2006

Links of interest:
- LinkedIn Professional profile: http://se.linkedin.com/in/jaimemross
- Article in NewScientist Magazine on PNAS publication:
http://www.newscientist.com/article/mg20827854.400-track-lactic-acid-to-discover-brain-age.html
- Article in National Geographic Deutschland on PNAS publication (in German): http://www.nationalgeographic.de/aktuelles/fruehwarnsystem-fuer-das-gehirn

Recent publications:
  • Ross JM. (in press). Visualization of mitochondrial respiratory function using cytochrome c oxidase / succinate dehydrogenase (COX/SDH) double-labeling histochemistry. JoVE.
  • Ross JM, Coppotelli G, and Olson L (2011). Reply to Quistorff and Grunnet: Dysfunctional mitochondria, brain lactate, and lactate dehydrogenase isoforms. PNAS 108: E22.
  • Ross JM, Öberg J, Brené S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ, Olson L (2010). High brain lactate is a hallmark aging and caused by a shift in the lactate dehydrogenase A/B ratio. PNAS 107: 20087-92.
  • Lin L, McCroskery S, Ross JM, Chak Y, Neuhuber B, Daniels MP (2010). Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases. Exp Cell Res 316: 2260-77.
  • Marques-Deak AH, Lotufo Neto F, Dominguez WV, Solis AC, Kurcgant D, Sato F, Ross JM and Prado EBA (2007). Cytokine profiles in women with different subtypes of Major Depressive Disorder. J Psychiatr Res 41: 152-9.
  • • Coppotelli G, Summers A, Chidakel A, Ross JM, and Celi FS (2006). Functional characterization of the 258 A/G (D2-ORFa-Gly-3Asp) human type-2 deiodinase polymorphism. A naturally occurring variant increases the enzymatic activity by removing a putative repressor site in the 5'UTR of the gene. Thyroid 16: 625-32.
Personal Statement:
I grew up in southern Vermont and attended St. Lawrence University, graduating magna cum laude in 2003 with a major in neuroscience concentrating in chemistry and a minor in fine arts. I have been attracted to biomedical research ever since I was a small child, when I experienced my grandmother's difficulty in walking due to lumbar spinal stenosis. I recall being intrigued by neurophysiology even in those days, when I used to experiment with different therapies and track my grandmother¹s performance on locomotive tasks, hoping to cure her degenerative spine.

Although I fully intended to become a neurosurgeon, I became very interested in 'learning and memory' circuitry as an undergraduate and studied the pharmacological effects of glial inhibition on the acquisition of new memories in the conscious rat. My experiences at St. Lawrence University opened my heart and mind to scientific discovery, especially to the exciting field of neuroscience.

Nowadays, I am using my passion for scientific discovery to further our understanding of the aging process. I have focused my attention on how changes in metabolism may influence the onset of age-related changes and neurodegenerative diseases. Recently, my colleagues and I published findings that high brain lactate is a biomarker of the aging process, and that proton magnetic resonance spectroscopy is a noninvasive strategy for monitoring, and possibly even predicting, aging phenotypes. My hope is that one day we can track how our brains are aging --we could ask our physicians for a 'brain check-up'! I plan to continue my quest to understand the relationship between damage to mitochondria ¬- the organelle responsible for energy production in the cell ¬- and changes in brain metabolism during the aging process.

For more information on my motivation for choosing the joint NIH-KI Graduate Partnerships Program, see:
http://ki.se/ki/jsp/polopoly.jsp?d=38592&a=127851&l=en



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 The KI-NIH Doctoral Program in Neuroscience is managed and supported by the Intramural Research Program of the National Institute of Mental Health (NIMH) and is part of the National Institutes of Health (NIH), a component of the U.S. Department of Health and Human Services.   NIH LOGO DHHS LOGO USA GOV LOGO