lab staff

About Us

Our mission is to determine the human genetic variation that contributes to the risk for mood and anxiety disorders such as bipolar disorder and panic disorder, so that better methods of diagnosis and treatment can be developed.

Recent Publications

<click here for pubmed listings>

RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder. Akula N, Barb J, Jiang X, Wendland JR, Choi KH, Sen SK, Hou L, Chen DT, Laje G, Johnson K, Lipska BK, Kleinman JE, Corrada-Bravo H, Detera-Wadleigh S, Munson PJ, McMahon FJ. Mol Psychiatry. 2014 Jan 7

Pharmacogenetics of antidepressants, mood stabilizers, and antipsychotics in diverse human populations. Murphy E, McMahon FJ. Discov Med. 2013 Sep;16(87):113-22.

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Cross-Disorder Group of the Psychiatric Genomics Consortium. Nat Genet. 2013 Sep;45(9):984-94.

Race, genetic ancestry and response to antidepressant treatment for major depression. Murphy E, Hou L, Maher BS, Woldehawariat G, Kassem L, Akula N, Laje G, McMahon FJ. Neuropsychopharmacology. 2013 Dec;38(13):2598-606.

Retention and attrition among African Americans in the STAR*D study: what causes research volunteers to stay or stray? Murphy EJ, Kassem L, Chemerinski A, Rush AJ, Laje G, McMahon FJ. Depress Anxiety. 2013 Nov;30(11):1137-44.

Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder. Moya PR, Wendland JR, Rubenstein LM, Timpano KR, Heiman GA, Tischfield JA, King RA, Andrews AM, Ramamoorthy S, McMahon FJ, Murphy DL. Mov Disord. 2013 Aug;28(9):1263-70.

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Cross-Disorder Group of the Psychiatric Genomics Consortium; Genetic Risk Outcome of Psychosis (GROUP) Consortium. Lancet. 2013 Apr 20;381(9875):1371-9.

Amish revisited: Next-generation sequencing studies of psychiatric disorders among the Plain people. Hou L, Faraci G, Chen DT, Kassem L, Schulze TG, Shugart YY, McMahon FJ. Trends Genet. 2013 Jul;29(7):412-8.

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. GENDEP Investigators; MARS Investigators; STAR*D Investigators. Am J Psychiatry. 2013 Feb 1;170(2):207-17.

Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, Kassem L, Park JH, Chatterjee N, Jamain S, Cheng A, Leboyer M, Muglia P, Schulze TG, Cichon S, Nöthen MM, Rietschel M; BiGS, McMahon FJ, Kelsoe JR, Greenwood TA, Nievergelt CM, McKinney R, Shilling PD, Schork NJ, Smith EN, Bloss CS, Nurnberger JI Jr, Edenberg HJ, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon FJ, Chen DT, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Schulze TG. Mol Psychiatry. 2013 Feb;18(2):195-205.

A systems approach to the biology of mood disorders through network analysis of candidate genes. Detera-Wadleigh SD & Akula N;. Pharmacopsychiatr. 2011, 44 (Suppl 1): S35-42.

A network-based approach to prioritize results from genome-wide association studies. Akula N, Baranova A, Seto D, Solka J, Nalls MA, Singleton A, Ferrucci L, Tanaka T, Bandinelli S, Cho YS, Kim YJ, Lee JY, Han BG; Bipolar Disorder Genome Study (BiGS) Consortium; Wellcome Trust Case-Control Consortium, McMahon FJ. PLoS One. 2011;6(9):e24220. Epub 2011 Sep 6.

The genetics of panic disorder. Schumacher J, Kristensen AS, Wendland JR, Nöthen MM, Mors O, McMahon FJ. J Med Genet. 2011 Jun;48(6):361-8. doi: 10.1136/jmg.2010.086876. Epub 2011 Apr 14. Review.

A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study. Liu X, Cannon DM, Akula N, Moya PR, Knudsen GM, Arentzen TE, Steele J, Laje G, Drevets WC, McMahon FJ. Mol Psychiatry. 2011 Jun;16(6):584-5. doi: 10.1038/mp.2011.1. Epub 2011 Feb 22.

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. McMahon FJ, Akula N, Schulze TG, Muglia P, Tozzi F, Detera-Wadleigh SD, Steele CJ, Breuer R, Strohmaier J, Wendland JR, Mattheisen M, Mühleisen TW, Maier W, Nöthen MM, Cichon S, Farmer A, Vincent JB, Holsboer F, Preisig M, Rietschel M; Bipolar Disorder Genome Study (BiGS) Consortium. Nat Genet. 2010 Feb;42(2):128-31. Epub 2010 Jan 17.

A genome-wide association study of amygdala activation in youths with and without bipolar disorder. Liu X, Akula N, Skup M, Brotman MA, Leibenluft E, McMahon FJ. J Am Acad Child Adolesc Psychiatry. 2010 Jan;49(1):33-41.

Pharmacogenetics studies in STAR*D: strengths, limitations, and results. Laje G, Perlis RH, Rush AJ, McMahon FJ. Psychiatr Serv. 2009 Nov;60(11):1446-57.

Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling. Gupta A, Schulze TG, Nagarajan V, Akula N, Corona W, Jiang XY, Hunter N, McMahon FJ, Detera-Wadleigh SD. Pharmacogenomics J. 2011 Mar 8. [Epub ahead of print]

Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB. Laje G, Cannon DM, Allen AS, Klaver JM, Peck SA, Liu X, Manji HK, Drevets WC, McMahon FJ. Int J Neuropsychopharmacol. 2010 Jul;13(6):715-24. Epub 2010 Jan 5.

Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. Laje G, Allen AS, Akula N, Manji H, John Rush A, McMahon FJ. Pharmacogenet Genomics. 2009 Sep;19(9):666-74.

Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Schulze TG, Detera-Wadleigh SD, Akula N, Gupta A, Kassem L, Steele J, Pearl J, Strohmaier J, Breuer R, Schwarz M, Propping P, Nöthen MM, Cichon S, Schumacher J; NIMH Genetics Initiative Bipolar Disorder Consortium, Rietschel M, McMahon FJ. Mol Psychiatry. 2009 May;14(5):487-91. Epub 2008 Dec 16.